GABAergic signalling to adult-generated neurons

J Physiol. 2008 Aug 15;586(16):3745-9. doi: 10.1113/jphysiol.2008.155713. Epub 2008 May 29.

Abstract

New neurons are continuously generated in discrete regions of the adult brain. In the hippocampus, newly generated cells undergo a step-wise progression of maturation that is regulated at multiple stages by a variety of physiological and pathological stimuli. Neural progenitors and newborn neurons initially receive exclusively GABAergic synaptic input, and accumulating evidence suggests that depolarizing actions of GABA contribute to activity-dependent regulation. Here we provide a brief overview of GABAergic signalling to newborn neurons in the hippocampus and describe how it regulates adult neurogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Adult Stem Cells / cytology*
  • Adult Stem Cells / physiology*
  • Cell Differentiation
  • Cell Proliferation
  • Humans
  • Neurons / cytology*
  • Neurons / physiology*
  • Neurotransmitter Agents / metabolism
  • Receptors, GABA / metabolism*
  • Signal Transduction / physiology*
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • Neurotransmitter Agents
  • Receptors, GABA
  • gamma-Aminobutyric Acid