Analysis of TP53 codon 72 polymorphism in HPV-positive and HPV-negative penile carcinoma

Cancer Lett. 2008 Sep 28;269(1):159-64. doi: 10.1016/j.canlet.2008.04.027. Epub 2008 May 29.


The association of the p53 polymorphism at codon 72 and susceptibility to develop human papillomavirus (HPV)-related cancer has been investigated in several studies with controversial results. In this study, 78 penile squamous cell carcinoma biopsies (n=17 from Uganda, n=61 from Italy) and blood samples from 150 healthy controls (n=57 from Uganda, n=93 from Italy) have been analyzed for the arginine and proline allele distribution. Among Ugandan cases the heterozygous, proline homozygous and arginine homozygous genotype frequency was 41.2%, 52.9% and 5.9%, respectively, and among controls was 40.3%, 54.4%, and 5.3%, respectively (P=0.9917). Conversely, among Italian cases genotype distribution was 42.6%, 4.9%, and 52.5%, and among controls was 34.4%, 7.5%, and 58.1%, respectively (P=0.5343). No significant differences in arginine and proline allele distribution were observed when the cases were stratified by HPV status. Therefore, no evidence of association between homozygosity for p53 arginine and HPV-related or HPV-unrelated penile squamous cell carcinoma was observed neither among Ugandan nor among Italian populations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Squamous Cell / ethnology
  • Carcinoma, Squamous Cell / genetics*
  • Carcinoma, Squamous Cell / virology
  • Codon*
  • Genes, p53*
  • Humans
  • Italy
  • Male
  • Middle Aged
  • Papillomaviridae / isolation & purification*
  • Penile Neoplasms / ethnology
  • Penile Neoplasms / genetics*
  • Penile Neoplasms / virology
  • Polymorphism, Genetic*
  • Uganda


  • Codon