Celecoxib anti-aromatase neoadjuvant (CAAN) trial for locally advanced breast cancer

J Steroid Biochem Mol Biol. 2008 Jul;111(1-2):13-7. doi: 10.1016/j.jsbmb.2008.04.004. Epub 2008 Apr 20.

Abstract

Objectives: To evaluate the efficacy and safety of combing aromatase inhibitor (AI) and cyclooxygenase-2 (COX-2) inhibitor neoadjuvantly in postmenopausal patients with invasive hormone-sensitive breast cancer.

Methods: Eighty-two patients were randomly assigned to receive exemestane 25mg daily and celecoxib 400mg twice daily (group A, n=30), exemestane 25mg daily (group B, n=24) and letrozole 2.5mg daily (group C, n=28).

Results: All groups showed clinical responses (58.6% for group A, 54.5% for group B and 62.0% for group C) and decrease in tumor area (61.8% for group A, 58.1% for group B and 55.7% for group C). 3 out of 5 patients with complete clinical response were observed from group A and 2 out of 69 patients operated with pathologic complete response were observed in group C. The mean microscopic tumor size was 2.53 cm for group A, 3.05 cm for group B and 2.10 cm for group C. The differences were only statistically significant when group C was compared with group B (P=0.025). The toxicity profiles among groups were satisfactory.

Conclusion: AI is effective in treating breast cancer and may be safely used preoperatively. The addition of COX-2 inhibitor may provide additional benefit.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Aged, 80 and over
  • Androstadienes / therapeutic use
  • Antineoplastic Agents / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Aromatase Inhibitors / therapeutic use*
  • Breast Neoplasms / blood
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / enzymology
  • Breast Neoplasms / pathology
  • Celecoxib
  • Cholesterol / blood
  • Cyclooxygenase 2 Inhibitors / therapeutic use*
  • Female
  • Humans
  • Lipids / blood
  • Middle Aged
  • Neoadjuvant Therapy
  • Postmenopause
  • Pyrazoles / therapeutic use*
  • Sulfonamides / therapeutic use*
  • Treatment Outcome
  • Tumor Burden

Substances

  • Androstadienes
  • Antineoplastic Agents
  • Aromatase Inhibitors
  • Cyclooxygenase 2 Inhibitors
  • Lipids
  • Pyrazoles
  • Sulfonamides
  • Cholesterol
  • Celecoxib
  • exemestane