Association of cannabis use with prodromal symptoms of psychosis in adolescence

Br J Psychiatry. 2008 Jun;192(6):470-1. doi: 10.1192/bjp.bp.107.045740.


Recent interest has focused on the association between cannabis use and risk of psychosis. In the largest unselected, population-based study on this topic to date, we examined cannabis use and prodromal symptoms of psychosis at age 15-16 years among 6330 adolescents. Those who had tried cannabis (n=352; 5.6% of the total sample) were more likely to present three or more prodromal symptoms even after controlling for confounders including previous behavioural symptoms (OR=2.23; 95% CI 1.70-2.94). A dose-response effect was seen. We conclude that cannabis use is associated with prodromal symptoms of psychosis in adolescence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Cohort Studies
  • Confounding Factors, Epidemiologic
  • Disease Susceptibility
  • Female
  • Humans
  • Male
  • Marijuana Smoking / adverse effects
  • Marijuana Smoking / epidemiology
  • Marijuana Smoking / psychology*
  • Psychotic Disorders / epidemiology*
  • Psychotic Disorders / etiology
  • Risk Factors