Complete Genome Sequence of the Complex Carbohydrate-Degrading Marine Bacterium, Saccharophagus Degradans Strain 2-40 T

PLoS Genet. 2008 May 30;4(5):e1000087. doi: 10.1371/journal.pgen.1000087.

Abstract

The marine bacterium Saccharophagus degradans strain 2-40 (Sde 2-40) is emerging as a vanguard of a recently discovered group of marine and estuarine bacteria that recycles complex polysaccharides. We report its complete genome sequence, analysis of which identifies an unusually large number of enzymes that degrade >10 complex polysaccharides. Not only is this an extraordinary range of catabolic capability, many of the enzymes exhibit unusual architecture including novel combinations of catalytic and substrate-binding modules. We hypothesize that many of these features are adaptations that facilitate depolymerization of complex polysaccharides in the marine environment. This is the first sequenced genome of a marine bacterium that can degrade plant cell walls, an important component of the carbon cycle that is not well-characterized in the marine environment.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alteromonadaceae / chemistry
  • Alteromonadaceae / enzymology
  • Alteromonadaceae / genetics*
  • Alteromonadaceae / metabolism
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Base Sequence
  • Chromosome Mapping*
  • Genome, Bacterial*
  • Glycoside Hydrolases / genetics
  • Glycoside Hydrolases / metabolism
  • Molecular Sequence Data
  • Polysaccharides / chemistry
  • Polysaccharides / genetics
  • Polysaccharides / metabolism*
  • Protein Transport
  • Seawater / microbiology*
  • Sequence Analysis, DNA
  • Signal Transduction
  • Substrate Specificity

Substances

  • Bacterial Proteins
  • Polysaccharides
  • Glycoside Hydrolases
  • carbohydrase