[Interrelation of vasomotor effects in the endothelium of the cerebral and main arteries in obstructive pulmonary diseases]

Ross Fiziol Zh Im I M Sechenova. 2008 Feb;94(2):206-11.
[Article in Russian]

Abstract

We have investigated vasomotor activity of the trunk and cerebral arteries in mice with obstructive pulmonary diseases. It was established, that endothelial dysfunction depends on the form of pulmonary disease and has regional vascular features. It was determined, that the maximal disturbances are shown in mice with chronic obstructive pulmonary disease. It express as infringement of regional autonomy vasomotor effects and pathological paradoxical vasoconstriction of cerebral vessels. Bronchial asthma associates with the discordant answer of the brain and trunk arteries with the moderate adaptation of a regional homeostasis.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Flow Velocity / drug effects
  • Blood Flow Velocity / physiology
  • Carotid Artery, Common / drug effects
  • Carotid Artery, Common / physiology*
  • Disease Models, Animal
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / physiology*
  • Lung Diseases, Obstructive / physiopathology*
  • Magnetic Resonance Imaging
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Middle Cerebral Artery / drug effects
  • Middle Cerebral Artery / physiology*
  • Species Specificity
  • Vasoconstriction / drug effects
  • Vasoconstriction / physiology*