We have investigated vasomotor activity of the trunk and cerebral arteries in mice with obstructive pulmonary diseases. It was established, that endothelial dysfunction depends on the form of pulmonary disease and has regional vascular features. It was determined, that the maximal disturbances are shown in mice with chronic obstructive pulmonary disease. It express as infringement of regional autonomy vasomotor effects and pathological paradoxical vasoconstriction of cerebral vessels. Bronchial asthma associates with the discordant answer of the brain and trunk arteries with the moderate adaptation of a regional homeostasis.