Exploring the correlates of suicide attempts among individuals with major depressive disorder: findings from the national epidemiologic survey on alcohol and related conditions

J Clin Psychiatry. 2008 Jul;69(7):1139-49. doi: 10.4088/jcp.v69n0714.


Objective: There are no previous studies describing the correlates of suicide attempts in individuals with major depressive disorder in a nationally representative sample. This study explores the sociodemographic variables, mental disorders, and specific depressive symptoms associated with suicide attempts in depression.

Method: Data were drawn from Wave 1 of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), a large (N = 43,093) nationally representative survey of mental illness in the United States conducted between 2001 and 2002. Persons with lifetime major depressive disorder (N = 5128; diagnosed according to DSM-IV) were categorized according to the presence (N = 865) or absence (N = 4263) of a lifetime history of suicide attempts. Multivariate logistic regression was used to compare the 2 groups across a broad range of socio-demographic and mental disorder correlates, as well as to compare specific depressive symptoms associated with a history of suicide attempts. Positive predictive values (PPVs) were calculated to evaluate the effectiveness of each correlate in predicting suicide attempts. Analyses were conducted separately for men and women.

Results: Sociodemographic factors significantly associated with a history of suicide attempts included Hispanic or Latino ethnicity (p < .05), younger age (p < .01), and low annual income (p < .01). A history of suicide attempt was significantly associated with any anxiety, personality, or substance use disorder among both men and women (all p < .01). Personality disorder comorbidity was most predictive of suicide attempt. In men, suicide attempts had a strong association with dependent personality disorder (adjusted odds ratio [AOR] = 3.81; 95% CI = 1.14 to 12.73), whereas in women, suicide attempts had a strong association with antisocial personality disorder (AOR = 2.71; 95% CI = 1.72 to 4.25). Dependent personality disorder predicted suicide attempt in almost three quarters of depressed men (PPV = 74.3%; 95% CI = 54.2 to 87.6). The depressive symptom most strongly associated with a history of suicide attempts in both men and women was feelings of worthlessness (AOR = 5.48, 95% CI = 3.36 to 8.94 for men; AOR = 4.93, 95% CI = 3.56 to 6.84 for women).

Conclusions: This study contributes to the existing literature on risk factors for suicide attempts in depressed individuals. Identifying specific depressive symptoms and comorbid mental illnesses may improve the clinical assessment of suicide risk in people with major depressive disorder.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alcohol-Related Disorders / diagnosis
  • Alcohol-Related Disorders / epidemiology*
  • Alcohol-Related Disorders / psychology*
  • Alcoholism / diagnosis
  • Alcoholism / epidemiology*
  • Alcoholism / psychology*
  • Anxiety Disorders / diagnosis
  • Anxiety Disorders / epidemiology*
  • Anxiety Disorders / psychology*
  • Comorbidity
  • Cost of Illness
  • Depressive Disorder, Major / diagnosis
  • Depressive Disorder, Major / epidemiology*
  • Depressive Disorder, Major / psychology*
  • Diagnostic and Statistical Manual of Mental Disorders
  • Female
  • Humans
  • Male
  • Middle Aged
  • Population Surveillance / methods
  • Prevalence
  • Risk Factors
  • Severity of Illness Index
  • Suicide, Attempted / statistics & numerical data*
  • Surveys and Questionnaires*
  • United States / epidemiology