[Pulmonary silicosis and glomerular nephropathy. Apropos of 1 case]

Nephrologie. 1991;12(1):8-11.
[Article in French]


A 43-year-old stone cutter with 13 years of exposure to silica developed a pulmonary silicosis and a glomerulonephritis with moderate renal failure. Renal biopsy demonstrated in light microscopy a segmental and focal mesangial proliferation and in electron microscopy distinct alterations of the proximal tubular cells. Renal histology suggest silica may play a part in the pathogenesis of renal damage. Clinicians should therefore include silica exposure in the differential diagnosis of unexplained glomerulonephritis.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Glomerular Mesangium / pathology
  • Glomerulonephritis / etiology*
  • Glomerulonephritis / pathology
  • Humans
  • Kidney / pathology
  • Kidney Tubules, Proximal / pathology
  • Male
  • Microscopy, Electron
  • Silicon Dioxide*
  • Silicosis / complications*
  • Silicosis / pathology


  • Silicon Dioxide