Cell traffic and the lymphatic endothelium

Ann N Y Acad Sci. 2008;1131:119-33. doi: 10.1196/annals.1413.011.


The principal immune function of the afferent lymphatics is to bear antigen and leukocytes from peripheral tissues to the draining lymph nodes. Recent research has shown that passage of leukocytes into the afferent lymphatic capillaries is far from an indolent process; rather it is carefully orchestrated by an array of adhesion molecules, as well as by chemokines and their receptors. Here we review the current knowledge of leukocyte trans-lymphatic endothelial migration and its role in the development of an immune response.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Movement / immunology*
  • Chemokine CCL21 / immunology
  • Dendritic Cells / immunology
  • Endothelium, Lymphatic / immunology
  • Endothelium, Lymphatic / metabolism*
  • Endothelium, Lymphatic / pathology
  • Humans
  • Intercellular Adhesion Molecule-1 / physiology
  • Leukocytes / immunology*
  • Leukocytes / metabolism
  • Leukocytes / pathology*
  • Models, Biological
  • Receptors, CCR7 / immunology
  • Vascular Cell Adhesion Molecule-1 / physiology


  • Chemokine CCL21
  • Receptors, CCR7
  • Vascular Cell Adhesion Molecule-1
  • Intercellular Adhesion Molecule-1