Towards noninvasive molecular fluorescence imaging of the human brain

Neurodegener Dis. 2008;5(5):296-303. doi: 10.1159/000135614. Epub 2008 Jun 3.


Fluorescence molecular brain imaging is a new modality allowing the detection of specific contrast agents down to very low concentration ranges (picomolar) in disease models. Here we demonstrate a first noninvasive application of fluorescence imaging in the human brain, where concentrations down to about 100 nM of a nonspecific dye were detected. We argue that due to its high sensitivity, optical molecular imaging of the brain is feasible, which - together with its bedside applicability - makes it a promising technique for use in patients.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / pathology*
  • Brain / physiopathology
  • Fluorescence*
  • Humans
  • Mice
  • Molecular Biology / methods
  • Sensitivity and Specificity
  • Spectroscopy, Near-Infrared / methods*