Oxytocin receptor-deficient mice developed late-onset obesity

Neuroreport. 2008 Jun 11;19(9):951-5. doi: 10.1097/WNR.0b013e3283021ca9.


The oxytocin receptor has been suggested to be involved in energy metabolism, such as food intake and energy consumption. Here, we demonstrate that oxytocin receptor-deficient (Oxtr-/-) male mice exhibited late-onset obesity with increases in abdominal fat pads and fasting plasma triglycerides. Daily food intake and spontaneous motor activity of Oxtr-/- mice were not significantly different as compared with wild-type mice. In contrast, brown adipose tissue in Oxtr-/- mice contained large lipid droplets and cold-induced thermogenesis was impaired. This study demonstrates that oxytocin receptor plays essential roles in the regulation of energy homeostasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipocytes, Brown / pathology
  • Age Factors
  • Animals
  • Blood Glucose
  • Cholesterol / blood
  • Eating / genetics
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Motor Activity / genetics
  • Obesity / blood
  • Obesity / genetics*
  • Obesity / pathology
  • Obesity / physiopathology
  • Receptors, Oxytocin / deficiency*
  • Thermosensing / physiology
  • Triglycerides / blood


  • Blood Glucose
  • Receptors, Oxytocin
  • Triglycerides
  • Cholesterol