Low-dose gamma knife radiosurgery for cavernous sinus hemangioma: report of 3 cases and literature review

Minim Invasive Neurosurg. 2008 Jun;51(3):140-6. doi: 10.1055/s-2008-1065346.


Optimal management of cavernous sinus hemangiomas remains unclear. Total microsurgical removal of these neoplasms may be extremely difficult due to their rich vascularization. Three cases of cavernous sinus hemangioma treated with low-dose Gamma Knife radiosurgery are presented. Marginal dose varied from 10 to 13 Gy. Treatment planning and radiation dosimetry were done with a goal of conformal and selective coverage of the lesion with 50% prescription isodose line using multiisocenter technique. In all cases significant shrinkage of the neoplasm was marked at 3 months after treatment. Mean volume reduction at 12 months after radiosurgery was 60% (range: 45-75%). In all patients the shrinkage of the neoplasm was accompanied by notable improvement of the preexistent oculomotor nerve palsy. No radiosurgery-related complications were met during follow-up. In conclusion, low-dose Gamma Knife radiosurgery seems to be very effective for management of cavernous sinus hemangiomas, and can be considered as a treatment modality of choice for these lesions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Brain Neoplasms / diagnosis
  • Brain Neoplasms / pathology
  • Brain Neoplasms / surgery*
  • Cavernous Sinus / pathology
  • Cavernous Sinus / surgery*
  • Diagnosis, Differential
  • Female
  • Follow-Up Studies
  • Hemangioma, Cavernous, Central Nervous System / diagnosis
  • Hemangioma, Cavernous, Central Nervous System / pathology
  • Hemangioma, Cavernous, Central Nervous System / surgery*
  • Humans
  • Magnetic Resonance Imaging, Interventional
  • Male
  • Microsurgery
  • Middle Aged
  • Neuronavigation*
  • Postoperative Complications / diagnosis
  • Postoperative Complications / surgery
  • Radiosurgery*
  • Reoperation
  • Tomography, X-Ray Computed