Effect of consuming different caloric sweeteners on bone health and possible mechanisms

Nutr Rev. 2008 Jun;66(6):301-9. doi: 10.1111/j.1753-4887.2008.00037.x.


Western diets are high in caloric sweeteners and since the 1980s there has been a shift from the use of sucrose as the predominant sweetener to high-fructose corn syrup. This may have important implications for bone, as sugar consumption has been shown to negatively impact mineral balance. This article reviews the existing scientific evidence regarding the effect of caloric sweeteners and the type of sweetener on bone health and the potential mechanisms of action. A better understanding of the role of sugar consumption on mineral balance and bone can contribute to the determination of dietary recommendations to reduce bone loss and the future risk of osteoporosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bone Density / drug effects*
  • Bone Density / physiology
  • Bone and Bones / drug effects*
  • Bone and Bones / metabolism*
  • Calcium / metabolism
  • Dietary Sucrose / administration & dosage*
  • Evidence-Based Medicine
  • Fructose / administration & dosage
  • Homeostasis
  • Humans
  • Sweetening Agents / administration & dosage*


  • Dietary Sucrose
  • Sweetening Agents
  • Fructose
  • Calcium