A mouse plasma peptide atlas as a resource for disease proteomics

Genome Biol. 2008;9(6):R93. doi: 10.1186/gb-2008-9-6-r93. Epub 2008 Jun 3.


We present an in-depth analysis of mouse plasma leading to the development of a publicly available repository composed of 568 liquid chromatography-tandem mass spectrometry runs. A total of 13,779 distinct peptides have been identified with high confidence. The corresponding approximately 3,000 proteins are estimated to span a 7 logarithmic range of abundance in plasma. A major finding from this study is the identification of novel isoforms and transcript variants not previously predicted from genome analysis.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Alternative Splicing
  • Animals
  • Databases, Protein*
  • Humans
  • Mice
  • Peptides / analysis*
  • Plasma / chemistry*
  • Protein Isoforms
  • Proteomics
  • Tandem Mass Spectrometry


  • Peptides
  • Protein Isoforms