Medial necrosis due to sirolimus-eluting stent implantation in human coronary artery

J Cardiol. 2008 Feb;51(1):60-4. doi: 10.1016/j.jjcc.2007.08.001. Epub 2008 Feb 6.

Abstract

We report an autopsy case showing medial necrosis at the segment of sirolimus-eluting stent implantation. These findings indicate that cytotoxic effects of sirolimus can induce late-acquired incomplete stent apposition and/or aneurysmal changes after stenting in human coronary arteries.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Autopsy
  • Coronary Disease / etiology*
  • Coronary Restenosis / prevention & control
  • Drug-Eluting Stents / adverse effects*
  • Humans
  • Male
  • Necrosis / chemically induced
  • Sirolimus / administration & dosage*
  • Sirolimus / adverse effects*
  • Tunica Intima / pathology

Substances

  • Sirolimus