Endosomal sorting and signalling: an emerging role for sorting nexins

Nat Rev Mol Cell Biol. 2008 Jul;9(7):574-82. doi: 10.1038/nrm2427. Epub 2008 Jun 4.


The endocytic network comprises a series of interconnected tubulo-vesicular membranous compartments that together regulate various sorting and signalling events. Although it is clear that defects in endocytic function underlie a variety of human diseases, our understanding of the molecular entities that regulate these sorting and signalling events remains limited. Here we discuss the sorting nexins family of proteins and propose that they have a fundamental role in orchestrating the formation of protein complexes that are involved in endosomal sorting and signalling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carrier Proteins / classification
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism*
  • Endocytosis / physiology*
  • Endoplasmic Reticulum / metabolism
  • Endosomes / metabolism*
  • Humans
  • Intracellular Membranes / metabolism
  • Phylogeny
  • Protein Sorting Signals
  • Protein Transport / physiology
  • Signal Transduction / physiology*
  • Sorting Nexins
  • Vesicular Transport Proteins / classification
  • Vesicular Transport Proteins / genetics
  • Vesicular Transport Proteins / metabolism*


  • Carrier Proteins
  • Protein Sorting Signals
  • Sorting Nexins
  • Vesicular Transport Proteins