Whole-body MRI for Metastases Screening: A Preliminary Study Using 3D VIBE Sequences With Automatic Subtraction Between Noncontrast and Contrast Enhanced Images

Am J Clin Oncol. 2008 Jun;31(3):285-92. doi: 10.1097/COC.0b013e31815e3ff4.

Abstract

Objectives: To evaluate 3D Volumetric Interpolated Breath-hold Examination (VIBE) whole-body MRI (WB-MRI) acquisition for the metastases staging.

Methods: Thirty-two consecutive patients with solid tumor were examined from head to feet before and after contrast injection. An automatic subtraction occurred between the 2 series of images. WB-MRI was compared with conventional staging techniques (CT, scintigraphy, brain MRI, and whole-body PET in 4 cases).

Results: WB-MRI and the reference techniques depicted metastases in 25 patients. WB-MRI depicted more bone lesions in the spine, pelvis, skull, femur, and tibia, whereas scintigraphy detected more rib lesions. WB-MRI depicted 27 cerebral metastases, whereas brain MRI depicted 40 cerebral metastases. WB-MRI depicted a total of 8 hepatic metastases, 8 adrenal lesions, and conventional staging 7 hepatic metastases and 10 adrenal lesions. WB-MRI examination depicted lung metastases in 10 patients, and CT examination in 13 patients.

Conclusion: The results of this study indicate that WB-MRI is a feasible and promising technique for tumor staging.

MeSH terms

  • Adrenal Gland Neoplasms / diagnosis
  • Adrenal Gland Neoplasms / secondary
  • Adult
  • Aged
  • Bone Neoplasms / diagnosis
  • Bone Neoplasms / secondary
  • Brain Neoplasms / diagnosis
  • Brain Neoplasms / secondary
  • Breast Neoplasms / diagnosis
  • Colonic Neoplasms / diagnosis
  • Female
  • Humans
  • Image Enhancement / methods*
  • Imaging, Three-Dimensional / methods*
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / secondary
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / secondary
  • Lymphatic Metastasis
  • Magnetic Resonance Imaging / methods*
  • Male
  • Mass Screening
  • Middle Aged
  • Neoplasm Metastasis / diagnosis*
  • Neoplasm Metastasis / pathology
  • Neoplasm Staging
  • Ovarian Neoplasms / diagnosis
  • Skin Neoplasms / diagnosis
  • Skin Neoplasms / secondary
  • Subtraction Technique
  • Tomography, X-Ray Computed / methods
  • Uterine Neoplasms / diagnosis
  • Whole Body Imaging*