Thymosin alpha 1 provides short-term and long-term benefits in the reimplantation of avulsed teeth: a double-blind randomized control pilot study

Am J Emerg Med. 2008 Jun;26(5):574-7. doi: 10.1016/j.ajem.2007.09.007.


Background: This study investigates the short-term and long-term effects of thymosin alpha 1 (Talpha1) on reimplantation of avulsed teeth.

Methods and material: Seventy-three patients with avulsed teeth were double-blind randomly assigned to a control group and group that used Talpha1. The teeth were reimplanted after treatment with Talpha1 or saline. Patients were monitored for both short-term and long-term parameters.

Results: The thymosin group demonstrated a lower interferon, tumor necrosis factor alpha and interleukin-6 levels (P < .05) and higher white blood cell levels than the control group (P < .05). The thymosin group demonstrated greater periodontal healing (P < .05), less ankylosis (P < .05), less tooth movement, and greater lifetime of the replanted teeth.

Conclusion: The use of Talpha1 has both short-term and long-term beneficial effects during reimplantation of avulsed teeth.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adjuvants, Immunologic / therapeutic use*
  • Double-Blind Method
  • Female
  • Humans
  • Interferons / blood
  • Interleukin-6 / blood
  • Male
  • Pilot Projects
  • Thymalfasin
  • Thymosin / analogs & derivatives*
  • Thymosin / therapeutic use
  • Tooth Avulsion / blood
  • Tooth Avulsion / surgery*
  • Tooth Replantation / methods*
  • Treatment Outcome
  • Tumor Necrosis Factor-alpha / blood


  • Adjuvants, Immunologic
  • Interleukin-6
  • Tumor Necrosis Factor-alpha
  • Thymosin
  • Interferons
  • Thymalfasin