Deubiquitylation and regulation of the immune response

Nat Rev Immunol. 2008 Jul;8(7):501-11. doi: 10.1038/nri2337.


Ubiquitylation is a fundamental mechanism of signal transduction that regulates immune responses and many other biological processes. Similar to phosphorylation, ubiquitylation is a reversible process that is counter-regulated by ubiquitylating enzymes and deubiquitylating enzymes (DUBs). Despite the identification of a large number of DUBs, our knowledge of the function and activities of this family of enzymes is just starting to accumulate. As described in this Review, recent studies of several DUBs, in particular CYLD and A20, show that deubiquitylation has an important role in the regulation of both innate and adaptive immune responses.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / immunology*
  • B-Lymphocytes / metabolism
  • Endopeptidases / metabolism*
  • Humans
  • Immunity, Innate*
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Signal Transduction
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / metabolism
  • Tumor Suppressor Proteins / metabolism
  • Ubiquitin / metabolism*
  • Ubiquitin-Specific Proteases


  • Intracellular Signaling Peptides and Proteins
  • Tumor Suppressor Proteins
  • Ubiquitin
  • Endopeptidases
  • Ubiquitin-Specific Proteases