Fatal neonatal myocarditis caused by a recombinant human enterovirus-B variant

Pediatr Infect Dis J. 2008 Jul;27(7):668-9. doi: 10.1097/INF.0b013e31816b5d2a.

Abstract

We report a case of fatal myocarditis in a newborn infant who was infected with a human enterovirus detected by throat culture and RT-PCR for viral RNA in plasma. Whole genome sequence analysis revealed the virus to be a genomic chimera that likely arose from recombination between coxsackievirus B3 and two recently identified enteroviruses, EV 86 and EV97.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Enterovirus B, Human / isolation & purification*
  • Enterovirus Infections / diagnosis*
  • Fatal Outcome
  • Genome, Viral
  • Humans
  • Infant, Newborn
  • Male
  • Molecular Sequence Data
  • Myocarditis / virology*
  • Pharynx / virology
  • Plasma / virology
  • RNA, Viral / genetics
  • Recombination, Genetic
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sequence Analysis, DNA
  • Virus Cultivation

Substances

  • RNA, Viral