Reproducibility of TMS-Evoked EEG responses

Hum Brain Mapp. 2009 Apr;30(4):1387-96. doi: 10.1002/hbm.20608.


Navigated transcranial magnetic stimulation combined with electroencephalography (nTMS-EEG), allows noninvasive studies of cortical excitability and connectivity in humans. We investigated the reproducibility of nTMS-EEG in seven healthy subjects by repeating left motor and prefrontal cortical stimulation with a 1-week interval. TMS was applied at three intensities: 90, 100, and 110% of subjects' motor threshold (MT). The TMS-compatible neuronavigation system guaranteed precise repositioning of the stimulation coil. The responses were recorded by a 60-channel whole head TMS-compatible EEG amplifier. A high overall reproducibility (r > 0.80) was evident in nTMS-EEG responses over both hemispheres for both motor and prefrontal cortical stimulation. The results suggest that nTMS-EEG is a reliable tool for studies investigating cortical excitability changes in the test-retest designs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain Mapping*
  • Cerebral Cortex / physiology*
  • Electroencephalography / methods*
  • Evoked Potentials, Motor / physiology*
  • Female
  • Functional Laterality
  • Humans
  • Male
  • Reaction Time
  • Reproducibility of Results
  • Transcranial Magnetic Stimulation / methods*
  • Young Adult