Computational analyses of TBC protein family in eukaryotes

Protein Pept Lett. 2008;15(5):505-9. doi: 10.2174/092986608784567483.

Abstract

Tre-2/Bub2/Cdc16 domain-containing proteins (TBC proteins) participate in wide range cellular processes. With computational approaches, 137 non-redundant TBC proteins from five model organisms were identified and classified into 13 subfamilies base on molecular evolutionary tree. This phylogenetic analysis provides useful functional annotation of newly-identified TBC proteins and guides for further experimentation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Motifs*
  • Animals
  • Caenorhabditis elegans Proteins / chemistry
  • Caenorhabditis elegans Proteins / classification
  • Computational Biology / methods*
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / classification
  • Drosophila Proteins / chemistry
  • Drosophila Proteins / classification
  • Evolution, Molecular
  • GTPase-Activating Proteins / chemistry*
  • GTPase-Activating Proteins / classification*
  • Humans
  • Phylogeny
  • Protein Structure, Tertiary
  • Saccharomyces cerevisiae / chemistry
  • Saccharomyces cerevisiae Proteins / chemistry
  • Saccharomyces cerevisiae Proteins / classification
  • Sequence Alignment

Substances

  • Caenorhabditis elegans Proteins
  • DNA-Binding Proteins
  • Drosophila Proteins
  • GTPase-Activating Proteins
  • Saccharomyces cerevisiae Proteins