The susceptibility to vitiligo is associated with NF-E2-related factor2 (Nrf2) gene polymorphisms: a study on Chinese Han population

Exp Dermatol. 2008 Dec;17(12):1059-62. doi: 10.1111/j.1600-0625.2008.00752.x. Epub 2008 Jun 4.


Vitiligo is an acquired pigmentary disorder and its pathogenesis remains unclear. Oxidative stress is considered to be the initial pathogenic event in the melanocyte destruction. NF-E2-related factor2 (Nrf2) is a transcription factor regulating the expression of detoxifying and antioxidant genes. To investigate the association of the Nrf2 gene promoter polymorphisms with vitiligo in Chinese Han population, the genotypes of -686A/G, -684G/A and -650C/A and the genotyping of variable number of tandem repeat were detected. The data were analysed by the chi-square test and the risk was evaluated by calculating OR and 95% CI. There was statistically significant difference in genotypic and allelic frequencies of -650C/A between the two groups (P < 0.05). A(-650) allele was significantly associated with the risk for vitiligo (OR = 1.724, chi(2) = 18.096). Polymorphism of the Nrf2 gene promoter at -650C/A was associated with the development of vitiligo and A(-650) allele may be one of the risk factors.

Publication types

  • Letter

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Asian People
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • NF-E2-Related Factor 2 / genetics*
  • Odds Ratio
  • Polymorphism, Genetic*
  • Polymorphism, Single Nucleotide
  • Risk Factors
  • Sex Factors
  • Tandem Repeat Sequences / genetics
  • Vitiligo / genetics*
  • Vitiligo / pathology
  • Young Adult


  • NF-E2-Related Factor 2
  • NFE2L2 protein, human