Hypersensitivity reactions associated with endovascular devices

Contact Dermatitis. 2008 Jul;59(1):7-22. doi: 10.1111/j.1600-0536.2008.01351.x. Epub 2008 Jun 1.


Allergic reactions to endoprostheses are uncommon and reported in association with orthopaedic, dental, endovascular and other implanted devices. Hypersensitivity reactions to the biomaterials used in endovascular prostheses are among the infrequent reactions that may lead to local or systemic complications following cardiovascular therapeutic interventions. This article reviews potential immunotoxic effects of commonly used biomaterials. Reports of putative hypersensitivity reactions to endovascular devices, including coronary stents, perforated foramen occluders, pacemakers and implantable cardioverter defibrillators are also reviewed.

Publication types

  • Review

MeSH terms

  • Allergens / adverse effects*
  • Biocompatible Materials / adverse effects*
  • Biocompatible Materials / chemistry
  • Blood Vessel Prosthesis / adverse effects
  • Defibrillators, Implantable / adverse effects
  • Dermatitis, Allergic Contact / etiology*
  • Foramen Ovale, Patent / therapy
  • Heart Diseases / therapy
  • Humans
  • Hypersensitivity / etiology*
  • Metals / adverse effects*
  • Pacemaker, Artificial / adverse effects
  • Patch Tests
  • Prostheses and Implants / adverse effects*
  • Stents / adverse effects


  • Allergens
  • Biocompatible Materials
  • Metals