Glutathione: a novel treatment target in psychiatry

Trends Pharmacol Sci. 2008 Jul;29(7):346-51. doi: 10.1016/ Epub 2008 Jun 4.


There is accumulating evidence for oxidative stress mechanisms as common pathophysiological pathways in diverse psychiatric disorders, which offers novel treatment targets in oxidation biology systems. Of these the glutathione system has the most favourable theoretical foundation, given its dominance as the most generic of cellular antioxidants. Clinically, this hypothesis has been supported by several recently published studies that have reported on the efficacy of N-acetylcysteine, a glutathione precursor, in the treatment of various psychiatric disorders. This article outlines the multidimensional evidence that currently exists for oxidative stress mechanisms in psychiatric disorders and specifically discusses glutathione as a promising novel therapeutic target.

Publication types

  • Review

MeSH terms

  • Glutathione / metabolism*
  • Humans
  • Mental Disorders / drug therapy*
  • Mental Disorders / metabolism
  • Oxidative Stress / drug effects*


  • Glutathione