Multi-functional nanocarriers for targeted delivery of drugs and genes

J Control Release. 2008 Sep 10;130(2):121-8. doi: 10.1016/j.jconrel.2008.04.016. Epub 2008 Apr 29.


In this review article, we describe the different nano-platforms developed in our laboratory at Northeastern University in Boston, MA for the targeted delivery of drugs and genes. Special emphasis is placed on nano-platforms that offer opportunities for multi-functionalization to allow for targeted stimuli-responsive and/or simultaneous strategic delivery of multiple drugs, genes, as well as the combination of therapeutic systems with image contrast enhancers. Polymeric and lipid-based nanocarriers can provide versatile platforms for the delivery of multiple pharmacological agents, specifically to enhance therapeutic effect and overcome drug resistance in cancer. In addition, polymeric nanoparticles and nanoparticles-in-microsphere oral system (NiMOS) are useful for systemic and oral gene therapy, respectively.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Contrast Media / administration & dosage
  • DNA / administration & dosage
  • DNA / genetics
  • Drug Carriers / chemistry*
  • Gene Transfer Techniques*
  • Humans
  • Nanoparticles / chemistry*
  • Pharmaceutical Preparations / administration & dosage


  • Contrast Media
  • Drug Carriers
  • Pharmaceutical Preparations
  • DNA