Hematopoietic lineage commitment: miRNAs add specificity to a widely expressed transcription factor

Dev Cell. 2008 Jun;14(6):815-6. doi: 10.1016/j.devcel.2008.05.011.


MicroRNAs are important regulators of normal and malignant hematopoiesis. A paper by Lu et al. in this issue of Developmental Cell demonstrates how one microRNA, miR-150, plays a critical role in commitment of the erythroid-megakaryocyte progenitor by modulating the level of the widely expressed transcription factor MYB (or c-Myb).

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Lineage
  • Erythroid Cells / cytology
  • Erythroid Cells / metabolism*
  • Hematopoietic Stem Cells / cytology
  • Hematopoietic Stem Cells / metabolism*
  • Megakaryocytes / cytology
  • Megakaryocytes / metabolism*
  • Mice
  • Mice, Inbred C57BL
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Proto-Oncogene Proteins c-myb / genetics
  • Proto-Oncogene Proteins c-myb / metabolism*


  • MicroRNAs
  • Proto-Oncogene Proteins c-myb