Involvement of the choroid plexus in multiple sclerosis autoimmune inflammation: a neuropathological study

J Neuroimmunol. 2008 Aug 13;199(1-2):133-41. doi: 10.1016/j.jneuroim.2008.04.035. Epub 2008 Jun 9.


An immunological function has been proposed for the choroid plexus (CP). In multiple sclerosis (MS) brains, CPs show (immunohistochemistry to HLA-DR, CD3, CD20, CD68, VCAM-1, CD138) T lymphocytes in vessels and stroma, VCAM-1 expression on endothelia, intense HLA-DR immunostaining on cells in CP stroma, among CP epithelium and on epiplexus cells. CPs in control or amyotrophic lateral sclerosis brains do not show such inflammatory changes. Intense CP inflammation is observed in viral encephalitis. Changes in MS CPs suggest persisting immune activation, with intensity similar to acute encephalitis, even in MS phases in which neurodegeneration prevails. In MS, CPs could represent a site for lymphocyte entry in the CSF and for CSF antigens presentation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antigens, CD / biosynthesis
  • Brain Diseases / etiology
  • Brain Diseases / immunology
  • Brain Diseases / pathology*
  • Choroid Plexus / immunology
  • Choroid Plexus / metabolism
  • Choroid Plexus / pathology*
  • Endothelium, Vascular / metabolism
  • Female
  • HLA-DR Antigens / biosynthesis
  • Humans
  • Immunohistochemistry
  • Inflammation / immunology
  • Inflammation / metabolism
  • Inflammation / pathology*
  • Male
  • Middle Aged
  • Multiple Sclerosis / complications*
  • Multiple Sclerosis / immunology
  • Multiple Sclerosis / pathology
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocytes / immunology
  • Vascular Cell Adhesion Molecule-1 / biosynthesis


  • Antigens, CD
  • HLA-DR Antigens
  • Vascular Cell Adhesion Molecule-1