Antitumor activity of C-21 steroidal glycosides from Cynanchum auriculatum Royle ex Wight

Phytomedicine. 2008 Nov;15(11):1016-20. doi: 10.1016/j.phymed.2008.02.021. Epub 2008 Jun 9.

Abstract

The antitumor activities of six C-21 steroidal glycosides isolated from the root tuber of Cynanchum auriculatum Royle ex Wight were performed according to a microculture tetrazolium (MTT) method on human tumor cell lines SMMC-7721, MCF-7 and Hela. Of these compounds, caudatin-2,6-dideoxy-3-O-methy-β-D-cymaropyranoside and caudatin were found to be of the highest effects against human tumor cell line SMMC-7721 with IC(50) values of 13.49 and 24.95 μM, respectively. Then the in vivo assay further showed that caudatin-2,6-dideoxy-3-O-methy-β-D-cymaropyranoside and caudatin significantly inhibited the growth of transplantable H(22) tumors in mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Carbohydrate Sequence
  • Cell Line, Tumor
  • Cynanchum / chemistry*
  • Drug Screening Assays, Antitumor
  • Female
  • Glycosides / chemistry
  • Glycosides / pharmacology*
  • HeLa Cells / drug effects
  • Humans
  • Inhibitory Concentration 50
  • Male
  • Mice
  • Molecular Sequence Data
  • Molecular Structure
  • Plant Roots / chemistry
  • Saponins / pharmacology*
  • Steroids / pharmacology*
  • Xenograft Model Antitumor Assays

Substances

  • Antineoplastic Agents, Phytogenic
  • Glycosides
  • Saponins
  • Steroids
  • caudatin
  • caudatin-2,6-dideoxy-3-O-methylcymaropyranoside