Effect of probiotics, Bifidobacterium breve and Lactobacillus casei, on bisphenol A exposure in rats

Biosci Biotechnol Biochem. 2008 Jun;72(6):1409-15. doi: 10.1271/bbb.70672. Epub 2008 Jun 7.


Bisphenol A (BPA), a putative endocrine disruptor, may be taken up by humans via the diet and have adverse effects on human health. In this study, we evaluated whether the probiotics, Bifidobacterium breve strain Yakult (BbY) and Lactobacillus casei strain Shirota (LcS), could exert a protective effect against dietary exposure to BPA. A group of rats fed on a diet containing 5% BbY or 5% LcS showed three advantageous effects compared to the control group; (i) the area under the blood concentration-time curve of BPA after its oral administration was significantly decreased, (ii) the amount of BPA excreted in the feces was significantly greater (2.4 times), and (iii) the percentage of BPA bound to the sediment fraction of the feces was significantly higher. These results suggest that BbY and LcS reduced the intestinal absorption by facilitating the excretion of BPA, and that these probiotics may suppress the adverse effects of BPA on human health.

MeSH terms

  • Animal Feed
  • Animals
  • Benzhydryl Compounds
  • Bifidobacterium / chemistry*
  • Body Weight / drug effects
  • Feces / chemistry
  • Feces / microbiology
  • Female
  • Lacticaseibacillus casei / chemistry*
  • Phenols / blood
  • Phenols / pharmacology*
  • Probiotics / pharmacology*
  • Rats
  • Rats, Inbred F344


  • Benzhydryl Compounds
  • Phenols
  • bisphenol A