Short-term high dietary fructose intake had no effects on insulin sensitivity and secretion or glucose and lipid metabolism in healthy, obese adolescents

J Pediatr Endocrinol Metab. 2008 Mar;21(3):225-35. doi: 10.1515/jpem.2008.21.3.225.


There is virtually no information on the metabolic impact of dietary fructose intake in adolescents despite their high fructose consumption, particularly via sweetened beverages.

Aim: To determine the short-term metabolic effects of dietary fructose intake in obese adolescents.

Methods: Six volunteers (3 M/3 F; 15.2 +/- 0.5 yr; 35 +/- 2 kg/m2; 39 +/- 2% body fat) were studied twice following 7 d of isocaloric, isonitrogenous high carbohydrate (60% CHO; 25% fat) diets with fructose accounting for 6% and 24% of total energy intake, respectively (random order). Insulin sensitivity and secretion were analyzed by the stable labeled intravenous glucose tolerance test and glucose and lipid kinetics using GCMS.

Results: A fourfold increase in dietary fructose intake did not affect insulin sensitivity or secretion, glucose kinetics, lipolysis or glucose, insulin, C-peptide, triglycerides, HDL- and LDL-cholesterol concentrations.

Conclusions: In the short term, when energy intake is constant, dietary fructose per se is not a contributor to insulin resistance and hypersecretion in obese adolescents.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Blood Glucose / metabolism
  • C-Peptide / metabolism
  • Dietary Carbohydrates*
  • Energy Intake
  • Female
  • Fructose / administration & dosage*
  • Glucose Tolerance Test
  • Humans
  • Insulin / blood
  • Insulin / metabolism*
  • Insulin Resistance*
  • Insulin Secretion
  • Lipid Metabolism*
  • Male
  • Obesity / metabolism*


  • Blood Glucose
  • C-Peptide
  • Dietary Carbohydrates
  • Insulin
  • Fructose