Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance

Adv Drug Deliv Rev. 2008 Sep;60(12):1421-34. doi: 10.1016/j.addr.2008.04.012. Epub 2008 Apr 24.


Antibodies have proven to be effective agents in cancer imaging and therapy. One of the major challenges still facing the field is the heterogeneous distribution of these agents in tumors when administered systemically. Large regions of untargeted cells can therefore escape therapy and potentially select for more resistant cells. We present here a summary of theoretical and experimental approaches to analyze and improve antibody penetration in tumor tissue.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antibodies / metabolism*
  • Antibodies / therapeutic use
  • Antibody Affinity
  • Antigens / physiology*
  • Biological Transport
  • Capillary Permeability
  • Diffusion
  • Endocytosis
  • Humans
  • Metabolic Clearance Rate
  • Models, Theoretical
  • Neoplasm Metastasis
  • Neoplasms / metabolism
  • Neoplasms / therapy*
  • Permeability


  • Antibodies
  • Antigens