Detailed visualization of the anterior segment using fourier-domain optical coherence tomography

Arch Ophthalmol. 2008 Jun;126(6):765-71. doi: 10.1001/archopht.126.6.765.


Objective: To study details of the anterior chamber drainage angle using Fourier-domain optical coherence tomography in healthy subjects and patients with angle abnormalities.

Methods: A high-speed anterior segment optical coherence tomography prototype was developed using a 1310-nm-wavelength swept light source. Six healthy subjects and 6 patients with glaucoma were imaged in an observational cross-sectional study.

Results: Schlemm's canal and the trabecular meshwork were visualized in all of the patients. Fifteen-millimeter scans enabled entire anterior segment visualization providing configuration details of the iris with respect to the angle. Four-millimeter scans permitted detailed views of the angle configuration and its structures. Volumetric imaging was possible and Schlemm's canal was visualized along part of its circumference.

Conclusion: Anterior segment Fourier-domain optical coherence tomography permits detailed noncontact imaging of the angle and its structures, providing a tool to improve our understanding of the pathogenesis of narrow-angle glaucoma.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anterior Eye Segment / pathology*
  • Cross-Sectional Studies
  • Fourier Analysis*
  • Glaucoma, Angle-Closure / diagnosis*
  • Gonioscopy
  • Humans
  • Iris / pathology
  • Middle Aged
  • Tomography, Optical Coherence / methods*
  • Trabecular Meshwork / pathology