An exploratory analysis of neurocognition in methamphetamine-induced psychotic disorder and paranoid schizophrenia

Cogn Behav Neurol. 2008 Jun;21(2):98-103. doi: 10.1097/WNN.0b013e31816bdf90.

Abstract

Objective: This exploratory study compared the neurocognitive performances of individuals with methamphetamine-induced psychotic disorder (MA psychosis) and paranoid schizophrenia.

Background: MA psychosis presents very similarly to paranoid schizophrenia and the relationship between the 2 disorders is not well-understood. Neurocognitive functioning is one potential factor for comparison, as deficits are documented in both schizophrenia and methamphetamine dependence.

Method: Participants were selected through chart review. Neurocognitive test scores for participants with paranoid schizophrenia (n=20) and MA psychosis (n=19) were obtained from hospital records and compared.

Results: Results of multivariate analysis of variance found no significant differences between the groups in any neurocognitive domain.

Conclusions: These preliminary findings suggest that similarities between the disorders may extend to neurocognition. Low power and sampling limitations may contribute to the null findings.

MeSH terms

  • Adult
  • Amphetamine-Related Disorders / diagnosis*
  • Amphetamine-Related Disorders / psychology
  • Amphetamine-Related Disorders / rehabilitation
  • Central Nervous System Stimulants / toxicity*
  • Cognition Disorders / chemically induced*
  • Cognition Disorders / diagnosis
  • Diagnosis, Differential
  • Female
  • Humans
  • Male
  • Methamphetamine / toxicity*
  • Neuropsychological Tests* / statistics & numerical data
  • Psychometrics
  • Psychoses, Substance-Induced / diagnosis*
  • Psychoses, Substance-Induced / psychology
  • Reproducibility of Results
  • Schizophrenia, Paranoid / chemically induced
  • Schizophrenia, Paranoid / diagnosis*
  • Schizophrenia, Paranoid / psychology
  • Schizophrenia, Paranoid / rehabilitation

Substances

  • Central Nervous System Stimulants
  • Methamphetamine