Abstract
Pyrrole 2-carboxylic acid (L5) was found to be an effective ligand for the Cu-catalyzed monoarylation of anilines with aryl iodides and bromides. Under the reported conditions (10% CuI/20% L5/DMSO/K3PO 4/80-100 degrees C/20-24 h), a variety of useful functional groups were tolerated, and moderate to good yields of the diaryl amine products were obtained.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Aniline Compounds / chemistry*
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Catalysis
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Copper / chemistry*
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Halogens / chemistry*
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Hydrocarbons, Cyclic / chemistry*
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Molecular Structure
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Proline / analogs & derivatives*
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Proline / chemistry
Substances
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Aniline Compounds
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Halogens
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Hydrocarbons, Cyclic
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2-pyrrolecarboxylic acid
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Copper
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Proline