New Insights Into Mechanism and Regulation of Actin Capping Protein

Int Rev Cell Mol Biol. 2008;267:183-206. doi: 10.1016/S1937-6448(08)00604-7.

Abstract

The heterodimeric actin capping protein, referred to here as "CP," is an essential element of the actin cytoskeleton, binding to the barbed ends of actin filaments and regulating their polymerization. In vitro, CP has a critical role in the dendritic nucleation process of actin assembly mediated by Arp2/3 complex, and in vivo, CP is important for actin assembly and actin-based process of morphogenesis and differentiation. Recent studies have provided new insight into the mechanism of CP binding the barbed end, which raises new possibilities for the dynamics of CP and actin in cells. In addition, a number of molecules that bind and regulate CP have been discovered, suggesting new ideas for how CP may integrate into diverse processes of cell physiology.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Actin Capping Proteins / chemistry*
  • Actin Capping Proteins / classification
  • Actin Capping Proteins / genetics
  • Actin Capping Proteins / metabolism*
  • Actins / metabolism*
  • Adaptor Proteins, Signal Transducing / metabolism
  • Animals
  • Carrier Proteins / metabolism
  • Cell Membrane / metabolism
  • Cytoskeletal Proteins / metabolism
  • Dynactin Complex
  • Intercellular Signaling Peptides and Proteins / metabolism
  • Microfilament Proteins
  • Microtubule-Associated Proteins / metabolism
  • Models, Molecular
  • Phylogeny
  • Protein Conformation
  • Protein Isoforms / chemistry*
  • Protein Isoforms / classification
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism*
  • Protein Subunits / chemistry
  • Protein Subunits / genetics
  • Protein Subunits / metabolism
  • Sarcomeres / metabolism
  • Sarcomeres / ultrastructure

Substances

  • Actin Capping Proteins
  • Actins
  • Adaptor Proteins, Signal Transducing
  • CD2-associated protein
  • Carmil1 protein, mouse
  • Carrier Proteins
  • Cytoskeletal Proteins
  • Dynactin Complex
  • Intercellular Signaling Peptides and Proteins
  • Microfilament Proteins
  • Microtubule-Associated Proteins
  • Protein Isoforms
  • Protein Subunits
  • myotrophin