Mitosis: towards a molecular understanding of chromosome behavior

Curr Opin Cell Biol. 1991 Feb;3(1):59-66. doi: 10.1016/0955-0674(91)90166-v.


The past year has seen important contributions made to resolving how chromosomes attach to and move on the mitotic spindle of animal cells. These include the findings that: kinetochore microtubules are derived from the asters (i.e. centrosomes); poleward chromosome motion need not be coupled to kinetochore microtubules disassembly; the motor for poleward chromosome motion is associated with the kinetochore; and immunological evidence that this motor is cytoplasmic dynein.

Publication types

  • Review

MeSH terms

  • Anaphase / physiology
  • Animals
  • Chromosomes / physiology*
  • Mitosis / physiology*
  • Spindle Apparatus / physiology