Nasal lavage with mupirocin for the treatment of surgically recalcitrant chronic rhinosinusitis

Laryngoscope. 2008 Sep;118(9):1677-80. doi: 10.1097/MLG.0b013e31817aec47.


Objectives/hypothesis: To examine the efficacy and tolerability of topical mupirocin for the management of surgically recalcitrant chronic rhinosinusitis (CRS) associated with Staphylococcus aureus infection.

Study design: Prospective open-label pilot study.

Methods: Patients with surgically recalcitrant CRS who had positive nasendoscopically guided cultures for Staphylococcus aureus were treated with twice daily nasal lavages containing 0.05% Mupirocin and lactated ringers salts. The duration of treatment was 3 weeks. Patients were assessed before and after treatment in terms of nasendoscopic findings, microbiology results, and Sinonasal Outcome Test (SNOT-20) and visual analogue scale questionnaires.

Results: Fifteen of 16 patients had improved nasendoscopic findings after treatment. Twelve of 16 patients noted overall symptom improvement. Fifteen of 16 patients had negative swab results for Staphylococcus aureus after treatment. Only minimal adverse effects were experienced.

Conclusions: Nasal Lavage with 0.05% Mupirocin may represent an effective and well tolerated alternative treatment for postsurgical recalcitrant CRS.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Intranasal
  • Adult
  • Aged
  • Aged, 80 and over
  • Chronic Disease
  • Endoscopy
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Mupirocin / administration & dosage*
  • Otorhinolaryngologic Surgical Procedures / adverse effects*
  • Pilot Projects
  • Prospective Studies
  • Rhinitis / diagnosis
  • Rhinitis / drug therapy*
  • Rhinitis / etiology
  • Sinusitis / diagnosis
  • Sinusitis / drug therapy*
  • Sinusitis / etiology
  • Staphylococcal Infections / complications
  • Staphylococcal Infections / drug therapy*
  • Staphylococcal Infections / microbiology
  • Staphylococcus aureus / isolation & purification
  • Surgical Wound Infection / complications
  • Surgical Wound Infection / drug therapy*
  • Surgical Wound Infection / microbiology
  • Therapeutic Irrigation
  • Treatment Outcome


  • Mupirocin