Design and fabrication of phantoms using stereolithography for small-animal imaging systems

Mol Imaging Biol. 2008 Sep;10(5):231-6. doi: 10.1007/s11307-008-0150-7. Epub 2008 Jun 11.


Purpose: We have investigated a new technology for fabricating phantoms with fine details for use in small-animal imaging.

Procedures: We used a high-resolution, 3-D stereolithography (SL) system to produce performance-evaluation phantoms such as cold-rod Derenzo, hot-channel Derenzo, and Defrise phantoms. SL performance was estimated by measuring the dimensions of many structures using a microscope. We also evaluated the degree of water absorption by two different SL resins, Somos 11120 and Accura 40, after curing.

Results: The average bias and precision of the cold-rod structures over the size range 0.5 to 1.0 mm, were -0.4% and 1.74%, respectively. The water absorption study showed that Somos 11120 is a more suitable material for nuclear medicine applications.

Conclusion: We have demonstrated that SL is a robust and accurate method for fabrication of phantoms for small-animal imaging systems.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adsorption
  • Animals
  • Body Size
  • Nuclear Medicine / methods*
  • Phantoms, Imaging*
  • Tomography, X-Ray Computed
  • Water / analysis
  • Water / chemistry


  • Water