Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population

Neurosci Lett. 2008 Jul 25;440(1):35-7. doi: 10.1016/j.neulet.2008.05.029. Epub 2008 May 15.

Abstract

Schizophrenia has been observed to be associated with various abnormalities in cytokines and cytokine receptors. Three very recent reports showed the evidence that the IL3 gene, colony stimulating factor 2 receptor alpha (CSF2RA), beta (CSF2RB) and IL-3 receptor alpha (IL3RA), the IL-specific receptor subunits for CSF2 and IL3, respectively, are associated with schizophrenia. To examine the association of the IL3RA polymorphism (rs6603272) with schizophrenia in a Chinese population, 310 physically healthy patients with schizophrenia were compared with 330 age-, sex- matched normal controls. Statistically significant differences were observed in both allelic and genotypic frequencies of the rs6603272 polymorphism (Allele, chi2=6.24, d.f.=1, p=0.013, odds ratio (OR)=1.35, 95% CI 1.07-1.71; Genotype, chi2=6.85, d.f.=2, p=0.033). Our results indicate a small but significant contribution of the IL3RA polymorphism to susceptibility to schizophrenia, suggesting that the IL3 pathway may be involved in schizophrenia.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alleles
  • Asian Continental Ancestry Group
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Humans
  • Interleukin-3 Receptor alpha Subunit / genetics*
  • Male
  • Polymorphism, Genetic / genetics*
  • Receptors, Interleukin-3 / genetics*
  • Schizophrenia / genetics*

Substances

  • IL3RA protein, human
  • Interleukin-3 Receptor alpha Subunit
  • Receptors, Interleukin-3