The consequence of concomitantly present functional genetic variants for the identification of functional genotype-phenotype associations in pain

Clin Pharmacol Ther. 2009 Jan;85(1):25-30. doi: 10.1038/clpt.2008.103. Epub 2008 Jun 11.


Genetics-based personalized approaches to pain management have received a setback because of the nonreproducibility of functional genetic associations such as the pain-modulatory effect of the catechol-O-methyl transferase (COMT) gene 472G>A single-nucleotide polymorphism. Given that many of the pain-relevant genetic variants are common (allelic frequencies of 10-50%), we hypothesized that a major reason for difficulties in reproducing demonstrations of genetic influences on pain is the concomitant presence in a single individual of several functional genetic polymorphisms that act as confounders.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Catechol O-Methyltransferase / genetics*
  • Female
  • Genotype
  • Heterozygote
  • Humans
  • Male
  • Middle Aged
  • Pain / genetics*
  • Pain Threshold
  • Phenotype
  • Polymorphism, Single Nucleotide / genetics*
  • Young Adult


  • Catechol O-Methyltransferase