Long-term effects of glans penis augmentation using injectable hyaluronic acid gel for premature ejaculation

Int J Impot Res. Jul-Aug 2008;20(4):425-8. doi: 10.1038/ijir.2008.26. Epub 2008 Jun 12.


The authors created the glans penis augmentation by injectable hyaluronic acid gel and reported the 6-month result for premature ejaculation. In a total of 38 patients, long-term effects of 5 years were compared to those of 6 months in terms of residual volume of implants and efficacy on premature ejaculation. Maximal glandular circumference measured by tapeline significantly decreased by 15% (P<0.05) but mean patient's visual estimation (Gr 0-Gr 4) did not decrease (3.60 vs 3.56, P>0.05). Compared to 6-month follow-up, intravaginal ejaculatory latency time and vibratory threshold decreased at 5 years (P<0.05), but still well increased considering those of preaugmentation. Hence, 76% of patients and 63% of partners were still satisfied. There was no serious adverse reaction. In the 5-year long-term follow-up of glans penis augmentation by filler, the implants were well maintained and effective for glans penis hypersensitivity in premature ejaculation patients.

MeSH terms

  • Adult
  • Ejaculation*
  • Erectile Dysfunction / physiopathology*
  • Erectile Dysfunction / surgery*
  • Female
  • Gels
  • Humans
  • Hyaluronic Acid*
  • Injections
  • Male
  • Middle Aged
  • Patient Satisfaction
  • Penis / surgery*
  • Prostheses and Implants
  • Time Factors


  • Gels
  • Hyaluronic Acid