Anxiolytic-like effect of chronic treatment with Erythrina velutina extract in the elevated plus-maze test

J Ethnopharmacol. 2008 Jul 23;118(2):295-9. doi: 10.1016/j.jep.2008.04.016. Epub 2008 Apr 24.


Introduction: In Brazil, Erythrina velutina (Fabaceae) is widely used as a tranquilizer and/or sedative, and its extract exerts an anxiolytic-like effect profile in animal models, although these results may be caused by its sedative or amnesic effects. AIMS, MATERIALS AND METHODS: Thus, this study evaluated the effect of acute and chronic (23-26 days) administrations of the hydroalcoholic extract of the stem bark of Erythrina velutina (orally) in mice submitted to the following tests: elevated plus-maze, forced swim, spontaneous locomotor activity, and habituation to active chamber. Chlordiazepoxide and imipramine were used as standard drugs.

Results: In the elevated plus-maze test, chronic, but not acute, Erythrina velutina (100mg/kg) administration increased the percentage of open arm entries, an effect also seen in both acute and chronic treatments with chlordiazepoxide (7.5mg/kg). In the forced swim test, only imipramine (25mg/kg) decreased immobility time. Impairment of habituation was seen only with acute imipramine administration and with the lowest doses of Erythrina velutina extract tested in acute (10mg/kg) and chronic (50mg/kg) administrations.

Conclusions: These results suggest that chronic administration of the hydroalcoholic extract of the stem bark of Erythrina velutina exerts an anxiolytic-like effect on mice, and it could serve as a new approach for the treatment anxiety, although it may have an amnesic effect at low doses.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Anti-Anxiety Agents / administration & dosage
  • Anti-Anxiety Agents / isolation & purification
  • Anti-Anxiety Agents / pharmacology*
  • Anxiety / drug therapy*
  • Behavior, Animal / drug effects
  • Brazil
  • Chlordiazepoxide / pharmacology
  • Disease Models, Animal
  • Drug Administration Schedule
  • Erythrina / chemistry*
  • Imipramine / pharmacology
  • Male
  • Maze Learning / drug effects
  • Medicine, Traditional
  • Mice
  • Motor Activity / drug effects
  • Plant Bark
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Swimming


  • Anti-Anxiety Agents
  • Plant Extracts
  • Chlordiazepoxide
  • Imipramine