Diffuse cerebral infarct associated with factor V Leiden and prothrombin 20210A mutations in a patient with tetralogy of Fallot

Clin Appl Thromb Hemost. 2009 Dec;15(6):705-7. doi: 10.1177/1076029608319883. Epub 2008 Jun 11.


A 2-year-old girl with tetralogy of Fallot presented with diffuse cranial infarct after cardiac angiography. Heterozygosity for factor V Leiden and prothrombin 20210A mutations were detected. The authors suggest that if thrombosis develops in patients with congenital heart disease, genetic risk factors should be evaluated.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Factor V / genetics*
  • Female
  • Genetic Predisposition to Disease
  • Heparin, Low-Molecular-Weight
  • Humans
  • Mutation*
  • Prothrombin / genetics
  • Stroke / drug therapy
  • Stroke / etiology
  • Stroke / genetics*
  • Tetralogy of Fallot / complications*
  • Warfarin


  • Heparin, Low-Molecular-Weight
  • factor V Leiden
  • Warfarin
  • Factor V
  • Prothrombin