Manganese-enhanced MRI: an exceptional tool in translational neuroimaging

Schizophr Bull. 2008 Jul;34(4):595-604. doi: 10.1093/schbul/sbn056. Epub 2008 Jun 11.


The metal manganese is a potent magnetic resonance imaging (MRI) contrast agent that is essential in cell biology. Manganese-enhanced magnetic resonance imaging (MEMRI) is providing unique information in an ever-growing number of applications aimed at understanding the anatomy, the integration, and the function of neural circuits both in normal brain physiology as well as in translational models of brain disease. A major drawback to the use of manganese as a contrast agent, however, is its cellular toxicity. Therefore, paramount to the successful application of MEMRI is the ability to deliver Mn2+ to the site of interest using as low a dose as possible while preserving detectability by MRI. In the present work, the different approaches to MEMRI in translational neuroimaging are reviewed and challenges for future identified from a practical standpoint.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Brain / pathology*
  • Brain / physiology*
  • Brain Diseases / diagnosis
  • Brain Diseases / pathology
  • Brain Mapping / methods
  • Chlorides / administration & dosage
  • Contrast Media / administration & dosage
  • Dose-Response Relationship, Radiation
  • Humans
  • Image Enhancement / methods*
  • Image Interpretation, Computer-Assisted
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Imaging / statistics & numerical data
  • Magnetic Resonance Imaging / trends
  • Manganese Compounds / administration & dosage
  • Manganese* / administration & dosage
  • Manganese* / adverse effects
  • Neurodegenerative Diseases / chemically induced
  • Rats
  • Songbirds


  • Chlorides
  • Contrast Media
  • Manganese Compounds
  • Manganese
  • manganese chloride