Colony-stimulating Factors in Inflammation and Autoimmunity

Nat Rev Immunol. 2008 Jul;8(7):533-44. doi: 10.1038/nri2356.

Abstract

Although they were originally defined as haematopoietic-cell growth factors, colony-stimulating factors (CSFs) have been shown to have additional functions by acting directly on mature myeloid cells. Recent data from animal models indicate that the depletion of CSFs has therapeutic benefit in many inflammatory and/or autoimmune conditions and as a result, early-phase clinical trials targeting granulocyte/macrophage colony-stimulating factor and macrophage colony-stimulating factor have now commenced. The distinct biological features of CSFs offer opportunities for specific targeting, but with some associated risks. Here, I describe these biological features, discuss the probable specific outcomes of targeting CSFs in vivo and highlight outstanding questions that need to be addressed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Arthritis / immunology
  • Arthritis / metabolism
  • Atherosclerosis / immunology
  • Atherosclerosis / metabolism
  • Autoimmunity / immunology*
  • Colony-Stimulating Factors / deficiency
  • Colony-Stimulating Factors / immunology*
  • Colony-Stimulating Factors / metabolism
  • Encephalomyelitis, Autoimmune, Experimental / immunology
  • Encephalomyelitis, Autoimmune, Experimental / metabolism
  • Humans
  • Inflammation / immunology*
  • Inflammation / metabolism
  • Lung Diseases / immunology
  • Lung Diseases / metabolism
  • Neoplasms / immunology
  • Neoplasms / metabolism
  • Nephritis / immunology
  • Nephritis / metabolism
  • Receptors, Colony-Stimulating Factor / immunology*
  • Receptors, Colony-Stimulating Factor / metabolism

Substances

  • Colony-Stimulating Factors
  • Receptors, Colony-Stimulating Factor