The design of polyvalent therapeutics

Chemistry. 2008;14(26):7738-47. doi: 10.1002/chem.200800278.

Abstract

This article reviews recent developments in the design of polyvalent ligands for in vivo applications. Topics discussed include the design of polyvalent inhibitors of toxins and viruses, the use of polyvalency for targeted drug delivery and imaging, and applications of polyvalency for enhancing or suppressing immune responses.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Drug Delivery Systems
  • Drug Design*
  • Humans
  • Immunosuppressive Agents / chemistry
  • Immunosuppressive Agents / pharmacology
  • Ligands
  • Protein Binding

Substances

  • Immunosuppressive Agents
  • Ligands