Localization of the human gene for 230-kDal bullous pemphigoid autoantigen (BPAG1) to chromosome 6pter----q15

Cytogenet Cell Genet. 1991;57(1):30-2. doi: 10.1159/000133108.

Abstract

Chromosome mapping of the human gene encoding the 230-kDal autoantigen of an autoimmune skin disease, bullous pemphigoid, was performed using flow-sorted human chromosomes of cells of normal karyotype and cells carrying a reciprocal translocation t(6;16)(q15;q24). The cDNA of the autoantigen hybridized with intact chromosome 6 and translocation chromosome 6p- (6pter----q15::16q24----qter). The gene (BPA230) was located to the chromosome region 6pter----q15.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoantigens / genetics*
  • Carrier Proteins*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 6*
  • Collagen*
  • Cytoskeletal Proteins*
  • DNA / genetics
  • Dystonin
  • Humans
  • Karyotyping
  • Mice
  • Nerve Tissue Proteins*
  • Non-Fibrillar Collagens*
  • Nucleic Acid Hybridization
  • Pemphigoid, Bullous / immunology*
  • Translocation, Genetic

Substances

  • Autoantigens
  • Carrier Proteins
  • Cytoskeletal Proteins
  • DST protein, human
  • Dst protein, mouse
  • Dystonin
  • Nerve Tissue Proteins
  • Non-Fibrillar Collagens
  • collagen type XVII
  • Collagen
  • DNA