The SH2D2A gene and susceptibility to multiple sclerosis

J Neuroimmunol. 2008 Jul 15;197(2):152-8. doi: 10.1016/j.jneuroim.2008.04.037. Epub 2008 Jun 12.


We previously reported an association between the SH2D2A gene encoding TSAd and multiple sclerosis (MS). Here a total of 2128 Nordic MS patients and 2004 controls were genotyped for the SH2D2A promoter GA repeat polymorphism and rs926103 encoding a serine to asparagine substitution at amino acid position 52 in TSAd. The GA(16)-rs926103()A haplotype was associated with MS in Norwegians (OR 1.4, P=0.04). A similar trend was observed among Danes. In the independent Norwegian, Danish and Swedish sample sets the GA(16) allele showed a combined OR of 1.13, P=0.05. Thus, the present study shows that the SH2D2A gene may contribute to susceptibility to MS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics*
  • Adolescent
  • Adult
  • Child
  • Confidence Intervals
  • Dinucleotide Repeats / genetics
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis / epidemiology
  • Multiple Sclerosis / genetics*
  • Odds Ratio
  • Polymorphism, Genetic / genetics*
  • Promoter Regions, Genetic / genetics*
  • Scandinavian and Nordic Countries / epidemiology


  • Adaptor Proteins, Signal Transducing
  • SH2D2A protein, human