Gold nanoparticles in delivery applications

Adv Drug Deliv Rev. 2008 Aug 17;60(11):1307-1315. doi: 10.1016/j.addr.2008.03.016. Epub 2008 Apr 10.


Gold nanoparticles (AuNPs) provide non-toxic carriers for drug and gene delivery applications. With these systems, the gold core imparts stability to the assembly, while the monolayer allows tuning of surface properties such as charge and hydrophobicity. An additional attractive feature of AuNPs is their interaction with thiols, providing an effective and selective means of controlled intracellular release.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Drug Delivery Systems / methods*
  • Gene Transfer Techniques
  • Gold / chemistry*
  • Humans
  • Metal Nanoparticles / chemistry*
  • Sulfhydryl Compounds / metabolism
  • Temperature


  • Sulfhydryl Compounds
  • Gold